KMID : 0614620000360010039
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Korean Journal of Gastroenterology 2000 Volume.36 No. 1 p.39 ~ p.45
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Expression of the High Mobility Group 1 mRNA in Gastric Cancer
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Park Dong-Il
Son Hee-Jung Song Sang-Yong Sohn Tae-Sung Kim Jae-Jun Kim Young-Ho Rhee Poong-Lyul Koh Kwang-Cheol Paik Seung-Woon Rhee Jong-Chul Choi Kyoo-Wan
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Abstract
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Background/Aims : High mobility group (HMG) proteins are nonhistone intranuclear architectural proteins involved in transcriptional regulation of gene. The purpose of this study was to investigate the role of HMG-1 protein expression in gastric cancer.
Methods : We obtained the biopsy specimens from 12 normal tissue, 14 patients with metaplastic gastritis, 14 patients with chronic atrophic gastritis, and 18 patients with gastric cancer. After performing comparative reverse transcription-polymerase chain reaction using GAPDH for these specimens, we analyzed the expression of HMG-1 mRNA semi-quantitatively. We investigated the relationship between the clinicopathologic findings and the level of HMG-1 mRNA expression in gastric cancer.
Results : The mean level of HMG-1/GAPDH ratio was 0.7¡¾0.07 in normal tissue, 0.9¡¾ 0.13 in gastritis, and 1.6¡¾0.40 in gastric cancer (p<0.05). There was no significant correlation between the levels of HMG-1 mRNA expression and several parameters such as age, gender, tumor size, depth of invasion, differentiation, Lauren¡¯s classification, and
lymph node metastasis in gastric cancer.
Conclusions : The expression of HMG-1 mRNA was increased significantly in patients with gastric cancer. The function and the mechanism of HMG-1 protein in tumorigenesis and tumor differentiation are still unclear. Thus, further study is needed to elucidate the relationship between HMG-1 expression and tumorigenesis or tumor differentiation.
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KEYWORD
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High Mobility group (HMG)-1 ´Ü¹é, À§¼±¾Ï, High mobility group (HMG)-1 protein, Gastric cancer,
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